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Psykiatrisk behandling er helt nødvendig hos smertepasienter som samtidig er deprimerte eller har mye angst. Det finnes også mange steder tilbud om å delta i mestringsgrupper sammen med andre med langvarige smerter. Høyspesialiserte metoder som nerveblokader, ryggmargsstimulering og andre nevrokirurgiske inngrep kan hjelpe noen.Fra et biokjemis
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